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When administered concomitantly with alcohol, loratadine has no potentiating effects as measured by psychomotor performance studies. Increases in plasma concentrations of loratadine have been reported after concomitant use with ketoconazole, erythromycin or cimetidine in controlled clinical trials, but without clinically significant changes (including electrocardiographic). Other drugs known to inhibit hepatic function metabolism should be coadministered with caution until definitive interaction studies can be completed.
Laboratory Test Interactions: Loratadine should be discontinued approximately, 48 hours prior to skin testing procedures since antihistamine may prevent or diminish otherwise positive reactions to dermal reactivity indicators.
